Total Synthesis of Calanthoside, a Potential Hair Growth Stimulant: A Facile Synthetic Approach via One-Pot S- and O-Glucosidic Bond Formation

    November 2023 in “ Journal of Natural Products ”
    Katsuki Takashima, Akane Asai, Mina Ashidate … Genzoh Tanabe
    Studysummary In this study, researchers accomplished the total synthesis of calanthoside, noted for its strong proliferative effects on human hair follicle dermal papilla cells, using a seven-step process from anthranilic acid with a 43% overall yield.
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    Research cited in this study 4

    1. Indole Glycosides from Calanthe Discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells Chemical & Pharmaceutical Bulletin · 2021
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    3. Differential Diagnosis of Headache and Vertigo: Topical Minoxidil Self-Medication Should Be Considered Journal of Headache & Pain Management · 2016
    4. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012