Switching roles: the functional plasticity of adult tissue stem cells

The document reviewed how adult tissue stem cells demonstrated functional plasticity by switching between states for homeostasis and regeneration in response to local and systemic challenges. It highlighted that differentiating cells could revert to stem cells after injury, showcasing their adaptability. The concept of the stem cell niche was expanded to include physical factors and hormonal signals that influence stem cell regulation. The review focused on the various functions of stem cells, the cellular mechanisms involved, and the signals that guide stem cells in switching roles.