The Role of the SWI/SNF ATP-Dependent Chromatin Remodeling Complex in the Regulation of Human Hair Follicle Cell Proliferation and Control of Human Cutaneous Wound Healing

The study investigated the role of SWI/SNF ATP-dependent chromatin remodeling complexes in human hair follicles and wound healing. It was found that genes encoding SWI/SNF complex subunits were expressed in human hair follicles, and siRNA suppression of these complexes did not affect hair growth or the anagen-catagen transition in the short term. However, there was a significant increase in the proliferation of outer root sheath keratinocytes. Additionally, the study highlighted the essential role of the core complex ATPase BRG1 in keratinocyte migration during wound closure, although it did not affect cell proliferation. This research provided insights into the diverse composition of SWI/SNF complex subunits in human epidermis and hair follicles, emphasizing the importance of BRG1 in wound healing processes.