Hair Growth Promoting Activity of Helianthus Annuus in Testosterone Induced Alopecia in Mice Model

The study demonstrated that Helianthus annuus (sunflower) oil promotes hair growth in a testosterone-induced alopecia model in Swiss albino mice. Thirty mice were divided into five groups of six each to test the effects of the oil at concentrations of 100 ml/kg and 200 ml/kg against a negative control, a testosterone-treated group, and a positive control treated with 2% minoxidil. The findings revealed that the group treated with 200 ml/kg of Helianthus annuus oil showed a significant increase in hair density (2.667 ± 0.2108) compared to the group treated with 100 ml/kg (2.167 ± 0.1667) and the testosterone-treated group (1.167 ± 0.3073), although minoxidil had the highest hair density (2.833 ± 0.1667). The study suggests that the oil's phytochemicals, which include saponins, steroids, and terpenoids, contribute to its hair growth effects due to their antioxidant, anti-inflammatory, and antiandrogenic properties, indicating its potential as a natural treatment for hair loss and androgenetic alopecia.