Extraction, Isolation, Characterization, and Biological Activity of Sulfated Polysaccharides Present in Ascidian Viscera Microcosmus Exasperatus

    October 2023 in “ Pharmaceuticals ”
    Ananda de Araujo Bento, Marianna Cardoso Maciel, Francisco Felipe Bezerra, Paulo Antônio de Souza Mourão, Mauro S.G. Pavão, Mariana P. Stelling
    Studysummary In this study, researchers investigated GAGs from the marine invertebrate Microcosmus exasperatus, finding that its polysaccharides possess antitumoral properties without affecting anticoagulant activity. The unique composition shows potential for cancer treatment when combined with existing therapies in future studies. Our plain-language summary of this paper — not a Tressless recommendation.
    The study on Microcosmus exasperatus explores its sulfated polysaccharides, identifying three distinct types, including fucosylated-dermatan sulfate. These polysaccharides exhibit potential antitumor properties, reducing tumor cell viability and migration in mouse Lewis lung carcinoma cells, while showing significantly lower anticoagulant activity than standard heparin. The research suggests that M. exasperatus could be a sustainable source for therapeutic polysaccharides, with promising applications in cancer treatment. The study involved 3 replicates for each assay, indicating a need for further research to confirm these findings.
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