Study on transdermal permeation and skin accumulation of finasteride ethosomes

January 2004 in “ Zhōnghuá yàoxué zázhì ”

Wenquan Liang

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The study investigated the use of liposomes and niosomes to enhance the concentration of finasteride in the dermis layer, which could aid in treating androgen-related skin disorders. Using hamster flank skin, the researchers found that drug-containing vesicles had an 80-97% drug entrapment efficiency. After 24 hours, 5.5-13% of finasteride penetrated the skin with vesicles, compared to 24% with a hydroalcoholic solution. DMPC liposomes resulted in the highest dermis concentration (7.8%). Vesicles significantly reduced drug permeation compared to the hydroalcoholic solution, demonstrating their potential to increase finasteride retention in the dermis.