The Stratum Corneum Barrier: Impaired Function in Relation to Associated Lipids and Proteins

    May 2024 in “ Tissue Barriers ”
    Jie Chen, Liu Changjie, Yuan Yang, Xue Gong, Huan Qian
    TLDR The skin's outer layer relies on lipids and proteins to protect against damage.
    The study highlights the role of keratinocytes in the formation and differentiation of the stratum corneum, the outermost layer of the epidermis, which serves as a critical barrier for the skin. It emphasizes that certain components of keratinocytes influence the stratum corneum's function, impacting its ability to protect against mechanical, physical, and chemical damage. This research underscores the importance of understanding the interactions between lipids and proteins in maintaining the integrity of the skin barrier.
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