Morphological and Inflammatory Changes in the Skin of Autopsied Fetuses According to the Type of Stress

    September 2015 in “ Pathology - Research and Practice ”
    Fernanda Rodrígues Helmo, Juliana Reis Machado, Lívia Ferreira Oliveira, Laura Penna Rocha, Camila Lourencini Cavellani, Vicente de Paula Antunes Teixeira, Marlene Antônia dos Reis, Rosana Rosa Miranda Corrêa
    TLDR Stress during pregnancy can thin fetal skin.
    The study investigated morphological and inflammatory changes in the skin of autopsied fetuses due to perinatal stress, analyzing 48 cases from the Federal University of Triângulo Mineiro. It found that the epidermis was thinner in fetuses that died from perinatal asphyxia (PA) and amniotic infection (AI) compared to those with congenital malformations (CM). The study suggested that chronic stress (CS) led to a thinner epidermis than acute stress (AS), with significant differences in gestational age and stress classification. The findings indicated that stress-related conditions, such as intrauterine growth restriction and psychological stress, were associated with reduced epidermal thickness and altered expression of proteins involved in epidermal proliferation.
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