Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

July 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Laura Ghanem (21751304), Najwaa Kirmani (21751307), María Paula Palacios-Ortiz (21751310), Martin Cevallos-Cueva (21751313), Daniela Lucía Mendoza-Millán (21751316), Gabriel Victor Almeida Nascimento (21751319), Virginia Velasco-Tamariz (21751322)

platelet-rich plasma androgenic alopecia single-spin centrifugation double-spin centrifugation hair density terminal hair vellus hair PRP AGA

TLDR Single-spin PRP may be more effective for hair loss, but more research is needed.

This systematic review and meta-analysis compared the efficacy of single-spin versus double-spin platelet-rich plasma (PRP) centrifugation methods in treating androgenic alopecia (AGA) across three randomized controlled trials involving 90 participants. The study found no significant difference in platelet concentration, hair density, or terminal and vellus hair rates between the two methods. However, the results suggest that single-spin PRP centrifugation may be more effective in treating AGA, although the differences were not statistically significant. The study highlights the need for further research to establish a standardized PRP treatment protocol for AGA.

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The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

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Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

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research Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

10 citations , September 2020 in “Archives of Dermatological Research”

Both methods improve hair density and thickness; double-spin may be more effective.

Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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