Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    July 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Laura Ghanem (21751304), Najwaa Kirmani (21751307), María Paula Palacios-Ortiz (21751310), Martin Cevallos-Cueva (21751313), Daniela Lucía Mendoza-Millán (21751316), Gabriel Victor Almeida Nascimento (21751319), Virginia Velasco-Tamariz (21751322)
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    Studysummary This study found no significant differences in platelet concentration or hair growth outcomes between single-spin and double-spin PRP centrifugation methods for treating androgenic alopecia, suggesting that the simpler single-spin approach may be preferable. Our plain-language summary of this paper — not a Tressless recommendation.
    This systematic review and meta-analysis compared the efficacy of single-spin versus double-spin platelet-rich plasma (PRP) centrifugation methods in treating androgenic alopecia (AGA) across three randomized controlled trials involving 90 participants. The study found no significant differences between the two methods in terms of platelet concentration, hair density improvement, or changes in terminal and vellus hair rates. Despite the lack of statistically significant differences, the study suggests that single-spin PRP centrifugation may be more effective for treating AGA.
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