Silencing Key Players of Androgenetic Alopecia Pathogenesis in Healthy Human Hair Follicles Ex Vivo Highlights the Hair Growth Inhibitory Effect of SFRP1

    September 2025 in “ Journal of the American Academy of Dermatology ”
    David Broadley, Alizée Le Riche, Yingyan Yu, Hanieh Erdmann, Mikhail Geyfman, Neil J. Poloso, J. Edelkamp, Marta Bertolini
    Image of study
    TLDR Reducing SFRP1 can promote hair growth and may help treat hair loss.
    This study investigates the role of androgen receptor (AR)-regulated genes in male pattern hair loss by examining their expression in human hair follicles ex vivo. The research highlights the expression of SFRP1 and DKK1 in different hair follicle compartments and their compensatory relationship. Knockdown of SFRP1 alone was found to prolong the anagen phase, increase keratinocyte proliferation, and decrease apoptosis, suggesting its potential as a therapeutic target for hair loss management. However, combined knockdown of SFRP1 and DKK1 did not provide additional benefits, emphasizing the complexity of targeting Wnt-signaling pathways for hair growth.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 2 years ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Fluridil degrades the androgen receptor.

      in Research/Science  12 upvotes 3 months ago
      Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  132 upvotes 1 year ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community Testosterone and Androgenetic Alopecia

      in Chat  7 upvotes 4 years ago
      How androgens, including testosterone, can cause hair follicles to miniaturize in people with sensitivity to androgens, and treatments such as finasteride, dutasteride, minoxidil, RU58841, or fluridil may be used in combination for long-term treatment.

    Related Research

    2 / 2 results