TLDR CXXC5 can both suppress and promote cancer, making it a complex target for treatment.
CXXC5, a member of the ZF-CXXC protein family, is a crucial regulator in cellular signaling networks, impacting processes like cell proliferation, differentiation, and apoptosis. It plays significant roles in cancer progression, acting as both a tumor suppressor and promoter depending on the cancer type, and is involved in pathways such as Wnt/β-catenin and TGF-β/BMP. CXXC5's inhibition has shown potential therapeutic applications in conditions like hair regeneration, skin healing, and bone formation. Its dual role in cancer necessitates careful consideration in treatment strategies, and further research is needed to fully understand its regulatory functions and potential as a diagnostic and therapeutic target.
May 2023 in “Skin research and technology” A DNA aptamer helps promote hair growth by enhancing a key cell growth signal in hair follicle cells.
Targeting CXXC5 and GSK-3β may help treat male pattern baldness.
318 citations,
January 2022 in “Signal Transduction and Targeted Therapy” The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
13 citations,
March 2021 in “British Journal of Pharmacology” KY19382 helps regrow hair and create new hair follicles.
28 citations,
November 2018 in “Journal of Cellular and Molecular Medicine” CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
8 citations,
September 2017 in “Journal of Investigative Dermatology” CXXC5 is a protein that prevents hair growth and could be a target for hair loss treatment.
37 citations,
June 2017 in “Journal of Investigative Dermatology” Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.
