Sonic Hedgehog Pathway in Wounds in Non-Diabetic Shh-Cre-eGFP/Ptch1-LacZ Mice Treated with MAA Beads

June 2016 in “ Biomaterials ”

Alexandra Lisovsky, Michael V. Sefton

sonic hedgehog signaling pathway Shh pathway Ptch1 MAA beads poly(methacrylic acid-co-methyl methacrylate) vascularization GFP+ cells β-Gal+ cells granulation tissue

TLDR MAA beads improved wound healing in male mice by activating the Shh pathway, but not in females.

The study investigated the effects of poly(methacrylic acid-co-methyl methacrylate) (MAA) beads on wound healing in non-diabetic Shh-Cre-eGFP/Ptch1-LacZ mice, focusing on the sonic hedgehog (Shh) signaling pathway. In non-diabetic male mice, MAA beads improved vascularization in large wounds by day 7 and increased the presence of GFP+ (Shh) and β-Gal+ (Ptch1) cells, indicating Shh pathway activation. This effect was also observed in the healthy skin surrounding the wound bed in males by day 4. In females, MAA beads modulated the Shh pathway within granulation tissue but did not enhance vascularization or affect the healthy skin. The study highlighted the importance of understanding the molecular mechanisms of MAA-based biomaterials and the need to test therapeutic efficacy in both sexes.

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