Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of β-Catenin, Dlk1, and COX-2

Shengfu oil, a traditional Chinese medicine with 16 ingredients, was studied for its effects on enhancing wound healing in rabbit full-thickness scalded skin. The study found that Shengfu oil significantly improved healing by exhibiting anti-inflammatory, analgesic, and antimicrobial activities. The oil led to intact wound tissue structures and regenerated cutaneous appendages, indicating superior healing compared to controls. Immunohistochemistry and multispectral imaging analysis revealed that Shengfu oil regulated the expression of β-catenin, Dlk1, and COX-2 proteins, with increased β-catenin and Dlk1 and decreased COX-2 expression during early wound repair, and fluctuating levels throughout the healing process. These findings suggested that Shengfu oil enhanced wound healing through its regulatory effects on these proteins.