TLDR The caffeine shampoo formulation is stable and suitable for treating hair loss.
The study focused on the pre-formulation of a shampoo containing caffeine for the treatment of androgenetic alopecia, a condition characterized by progressive hair loss. Caffeine was chosen due to its beneficial effects on this condition. The shampoo base was prepared to incorporate caffeine, and its stability was tested under various temperatures (5 ± 2ºC, 40 ± 2ºC, and 20 ± 2ºC) over 15 days. The formulation maintained good appearance, homogeneity, viscosity (11386 mPa.s), pH (6.28), and density (1.024 g/mL) throughout the testing period, indicating that the proposed formulation was stable and viable for compounding use.
13 citations
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January 2016 in “Journal of cosmetology & trichology” Alternative treatments show promise for hair growth beyond traditional methods.
11 citations
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July 2012 in “International Journal of Trichology” Caffeine may help hair growth in hereditary hair loss.
182 citations
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December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.
93 citations
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January 2007 in “Skin Pharmacology and Physiology” Caffeine in shampoo quickly enters the body through hair follicles.
224 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
8 citations
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January 2020 in “Skin Pharmacology and Physiology” Caffeine improves hair growth, thickness, and reduces shedding.
January 2025 in “Molecules” Caffeine may help with hair loss, but more research is needed to confirm its effectiveness.
10 citations
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April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
34 citations
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July 2010 in “Expert Opinion on Drug Delivery” The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.
5 citations
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September 2012 in “Springer eBooks” Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.
