Pre-Formulation Study of Shampoo for Androgenetic Alopecia Treatment Containing Caffeine as Active Ingredient

The study focused on the pre-formulation of a shampoo containing caffeine for the treatment of androgenetic alopecia, a condition characterized by progressive hair loss. The research aimed to utilize the follicular route for effective delivery of caffeine, which had shown beneficial effects in previous studies. The shampoo base was prepared and its stability was tested under various temperatures (5 ± 2ºC, 40 ± 2ºC, and 20 ± 2ºC) over 15 days. The formulation maintained good appearance, homogeneity, viscosity (11386 mPa.s), pH (6.28), and density (1.024 g/mL) throughout the testing period, indicating that the proposed formulation was stable and viable for compounding use.