Characteristics of Serum Immunoglobulin G N-Glycans in Male Patients With Androgenetic Alopecia
July 2025
in “
Chinese Journal of Dermatology
”
Studysummary This study reported differences in serum IgG N-glycans between male patients with different types of androgenetic alopecia, suggesting that GP10 and GP22 may serve as biomarkers for assessing hair loss severity in male FPHL. Our plain-language summary of this paper — not a Tressless recommendation.
This study investigated the serum immunoglobulin G (IgG) N-glycan profiles in 85 male patients with androgenetic alopecia (AGA), including 44 with male-pattern hair loss (MPHL) and 41 with female-pattern hair loss (FPHL). The research found significant differences in the N-glycan profiles between the two groups. FPHL patients had higher levels of certain N-glycans (GP5, GP11, GP17, GP20) and afucosylated IgG N-glycans, but lower levels of core fucosylated IgG N-glycans compared to MPHL patients. Additionally, N-glycans GP10 and GP22 were correlated with hair loss severity in FPHL patients, suggesting their potential as biomarkers for early assessment of hair loss severity. No significant differences were found in IgG N-glycan composition among MPHL patients with varying severity grades.
