Characteristics of Serum Immunoglobulin G N-Glycans in Male Patients With Androgenetic Alopecia

July 2025 in “ Chinese Journal of Dermatology ”

androgenetic alopecia male-pattern hair loss female-pattern hair loss N-glycans immunoglobulin G afucosylated IgG N-glycans core fucosylated IgG N-glycans biomarkers AGA MPHL FPHL IgG

TLDR Certain N-glycans may help assess hair loss severity in men with female-pattern hair loss.

This study investigated the serum immunoglobulin G (IgG) N-glycan profiles in 85 male patients with androgenetic alopecia (AGA), including 44 with male-pattern hair loss (MPHL) and 41 with female-pattern hair loss (FPHL). The research found significant differences in the N-glycan profiles between the two groups. FPHL patients had higher levels of certain N-glycans (GP5, GP11, GP17, GP20) and afucosylated IgG N-glycans, but lower levels of core fucosylated IgG N-glycans compared to MPHL patients. Additionally, N-glycans GP10 and GP22 were correlated with hair loss severity in FPHL patients, suggesting their potential as biomarkers for early assessment of hair loss severity. No significant differences were found in IgG N-glycan composition among MPHL patients with varying severity grades.

View this study on pifukezazhi.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 3 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 2 months ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 411 upvotes 6 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Losing Hair on Dutasteride? You might have LPP

in Research/Science 97 upvotes 7 months ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community can someone please tell me its going to get better? im bawling my eyes out

in Female 67 upvotes 3 years ago

A 16-year-old girl is experiencing hair loss, which has worsened despite using minoxidil and multivitamins. Suggestions include broader hormone testing and considering other treatments like spironolactone if the hair loss is due to androgenic alopecia.

Similar Research

6 / 1000+ results

research Evaluation and Management of the Hair Loss Patient in the Primary Care Setting

2 citations , October 2015 in “Primary Care: Clinics in Office Practice”

Doctors should diagnose hair loss by examining the patient and possibly doing tests, and then treat it based on the type, which may prevent permanent hair loss.

research The Genetically Programmed Hair Growth Cycle And Alopecia: What Is There To Know?

3 citations , June 2006 in “Expert Review of Dermatology”

The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.

research Guidelines on the Use of Finasteride in Androgenetic Alopecia

33 citations , January 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

Taking 1 mg of finasteride daily can increase hair count and improve hair appearance, but it may have side effects on sexual function and a potential risk of prostate cancer. It may not be effective for postmenopausal women unless taken in higher doses.

research Managing Patterned Hair Loss – A Hair Raising Task!

October 2021 in “Cosmoderma”

Hair loss can be managed with treatments like minoxidil, finasteride, and others, but there are still gaps in effectiveness and off-label usage is increasing.

research Light-Based Therapies in the Treatment of Alopecia

November 2024 in “Dermatology Online Journal”

Light-based therapies show promise as safe treatments for hair loss.

research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

8 citations , October 2022 in “Regenerative Therapy”

New regenerative treatments for hair loss show promise but need more research for confirmation.