Evaluation of Serum G Protein-Coupled Estrogen Receptor 1 Levels in Patients with Androgenetic Alopecia and Telogen Effluvium

This study evaluated serum G protein-coupled estrogen receptor 1 (GPER-1) levels in 84 participants divided into three groups: 28 with androgenetic alopecia (AGA), 28 with telogen effluvium (TE), and 28 healthy controls. The results showed a negative correlation between GPER-1 and estradiol (E2) levels. The AGA group had the highest mean GPER-1 levels, followed by the TE group, with the lowest levels in the controls. GPER-1 demonstrated moderate ability to distinguish between healthy controls and those with AGA or TE, but it was less effective in differentiating between AGA and TE cases. The study concludes that estrogen plays a significant role in hair growth, and serum GPER-1 levels could serve as a biomarker to differentiate AGA from TE and healthy controls.