Serum Adiponectin and Leptin in Patients With Alopecia Areata

This study investigated the relationship between serum adiponectin and leptin levels and alopecia areata (AA) in 50 patients with AA compared to 30 healthy controls. Results showed that AA patients had significantly lower adiponectin levels and higher leptin levels than controls. Leptin levels were positively correlated with fasting insulin and HOMA-IR, indicating a link with insulin resistance, and negatively correlated with HDL cholesterol, suggesting a connection to lipid metabolism. The findings suggest that these adipokines could be predictive factors for hair loss in AA and play a complex role in its pathogenesis.