Growth Inhibition of Mouse Skin Tumor by Serine Protease Inhibitor ONO-3403

September 2001 in “ PubMed ”

M Ohkoshi, Satoru Okuda

serine protease inhibitor ONO-3403 FOY-305 squamous cell carcinoma 3-methylcholanthrene

TLDR ONO-3403 effectively reduces mouse skin tumor growth without side effects.

The study investigated the effects of the serine protease inhibitor ONO-3403 on mouse skin tumors induced by 3-methylcholanthrene. ONO-3403, an analog of FOY-305, demonstrated significantly lower IC50 values against serine proteases like trypsin, plasmin, kallikrein, and thrombin compared to FOY-305. In the experiment, seven mice were administered ONO-3403 intraperitoneally at a dose of 4 mg/kg twice daily for 5 weeks. The treatment resulted in potent tumor growth suppression (p<0.001) without noticeable side effects such as hair loss or body weight loss. These findings suggested that ONO-3403 could be a potential treatment for squamous cell carcinoma.

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research Growth Inhibition of Mouse Skin Tumor by Serine Protease Inhibitor ONO-3403

1 citations , September 2001 in “PubMed”

ONO-3403 effectively reduces mouse skin tumor growth without side effects.