Scarless Wound Healing: A Literature Review

September 2019 in “ Romanian Journal of Pediatrics ”

Ancuta Muntean, Ionica Stoica, Dan Mircea Enescu

fetal skin scarless healing regenerative capabilities cellular mechanisms molecular mechanisms therapeutic targets postnatal wounds wound repair

Studysummary This review discusses the unique features of fetal wound healing that may enable scarless repair and reports no new experimental findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review discussed the potential of fetal skin to heal wounds without scarring, highlighting its regenerative capabilities. It emphasized the importance of understanding the cellular and molecular mechanisms behind this scarless healing phenotype, as it could lead to new therapeutic targets for reducing scarring in postnatal wounds. The review aimed to summarize the unique features of the fetal wound healing process that could facilitate scarless wound repair.

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research Scarless Wound Healing: Finding the Right Cells and Signals

132 citations , June 2016 in “Cell and Tissue Research”

This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.

research Improved Cutaneous Wound Healing After Intraperitoneal Injection of Alpha-Melanocyte-Stimulating Hormone

29 citations , November 2014 in “Experimental Dermatology”

This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

research Mammalian Fetal Organ Regeneration

32 citations , January 2005 in “Advances in Biochemical Engineering / Biotechnology”

This review discusses the unique capacity of fetal skin to heal wounds without scarring and notes that while many factors have been identified, the complete mechanism of fetal wound healing remains unclear.