Scalp Bacterial Species Influence SIRT1 And TERT Expression In Keratinocytes

September 2023 in “ Bioscience Biotechnology and Biochemistry ”

Azusa Yamada, Kota Watanabe, Yuri Nishi, Mugihito Oshiro, Yoshinori Katakura, Kenji Sakai, Yukihiro Tashiro

SIRT1 TERT keratinocytes Cutibacterium acnes Pseudomonas lini Staphylococcus epidermidis HaCaT cells longevity genes scalp bacteria skin cells

Studysummary In this study, predominant scalp bacteria, such as Cutibacterium acnes and Pseudomonas lini, were found to influence the expression of genes related to scalp and hair health in keratinocytes, potentially affecting scalp repair and hair growth. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the influence of scalp bacteria on the expression of longevity genes SIRT1 and TERT in human keratinocytes using HaCaT cells. It was found that certain bacteria, such as Cutibacterium acnes and Pseudomonas lini, enhance the expression of these genes, while Staphylococcus epidermidis represses them. These findings suggest that the predominant scalp bacteria play a role in scalp and hair health by regulating gene expression in keratinocytes, potentially impacting scalp repair and hair growth.

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