TLDR High S100B protein levels indicate poor survival in advanced melanoma.
The document discussed the increasing incidence of melanoma and highlighted the S100 protein family member S100B as a significant prognostic marker, particularly for stage IV melanoma, as incorporated into the AJCC melanoma staging system. High serum levels of S100B were associated with poor survival rates, and its prognostic value in earlier melanoma stages was under investigation. The role of S100B in melanoma progression, including tumor development, invasion, and metastasis, was not fully understood, and the document explored the relationship between S100 proteins and their receptor, RAGE, in melanoma biology.
72 citations
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June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
50 citations
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September 2023 in “Biomarker Research” S100A6 is important for cell functions and can help diagnose and treat diseases.
252 citations
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April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
12 citations
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August 2022 in “Biochemical Journal” Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.
1 citations
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April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
45 citations
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July 2009 in “Journal of Investigative Dermatology” The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.
