Effects of Russelia Equisetiformis Methanol and Aqueous Extracts on Hepatic Function Indices

The study investigated the effects of Russelia equisetiformis extracts on liver function in rats, revealing that both methanol and aqueous extracts, administered at doses of 100mg/kg, 200mg/kg, and 400mg/kg over 28 days, led to significant dose-dependent increases in total bilirubin, ALT, AST, and alkaline phosphatase levels, alongside a reduction in serum protein. These changes were more pronounced with the methanol extract, indicating that chronic use of these extracts could impair normal liver function.