Defining the Role of Primary Cilia on Skin-Derived Precursors

December 2012 in “ Journal of undergraduate research in Alberta ”

Sarthak Sinha, Ranjan Kumar, Jeff Biernaskie

primary cilia Skin Derived Precursors hair follicles lithium chloride Platelet Derived Growth Factor PDGF stem cells ciliary signaling

TLDR Elongating cilia boosts SKP stem cell renewal, especially with PDGF.

The study investigated the role of primary cilia in Skin Derived Precursors (SKPs), which are multipotent stem cells located at the base of hair follicles. Researchers confirmed the presence of cilia in SKPs and explored the effects of cilia elongation using lithium chloride. They found that elongating cilia enhanced the self-renewal capacity of SKPs, especially when combined with Platelet Derived Growth Factor (PDGF), suggesting that ciliary signaling may amplify PDGF effects on SKP proliferation. Future experiments were planned to further understand the role of cilia in SKPs and explore potential therapeutic applications for stem cell-based therapies.

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