TLDR MEF2C is crucial for normal hair cycle progression.
This study investigates the role of myocyte enhancer factor 2c (MEF2C) in hair follicle cycling, focusing on its interaction with the dermal papilla (DP) cells that regulate hair regeneration. Using DP-specific conditional knockouts (cKO) of Mef2c, researchers observed a significant delay in the early stages of catagen in hair follicles, suggesting MEF2C's crucial role in hair cycle progression. Preliminary findings indicate that SRY-box transcription factor 18 (Sox18), a binding partner of MEF2C, is upregulated in cKO mice, hinting at a potential regulatory mechanism. Understanding this interaction could lead to new treatments for hair loss disorders.
21 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations
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May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
1 citations
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December 2012 in “Journal of Dermatological Science” 158 citations
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February 2012 in “Journal of Investigative Dermatology” 95 citations
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July 2006 in “British Journal of Dermatology” Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.
