Role of Human Skin Antimicrobial Peptides in Psoriasis

The study evaluated human antimicrobial peptides (AMPs) in relation to inflammation in skin biopsies from 9 psoriasis patients and 1 healthy volunteer. Results showed significant inflammatory cell infiltration and varying levels of defensin-containing cells, PGP 9.5-containing nerve fibers, and MMP2 positive cells. Apoptosis was observed in epithelial, connective tissue, and inflammatory cells. Psoriatic lesions, especially in patients with no prior active treatment, exhibited marked activation of defensin, matrix metalloproteinase, and neuropeptides. The findings suggested a close correlation between the expression of defensin-containing cells, apoptotic cells, and inflammation, indicating that specific inflammation might stimulate AMPs and apoptosis.