RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers
October 2014
in “
International Journal of Molecular Sciences
”
TLDR Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.
This study investigated the effects of tanshinone IIA (TSA) pretreatment on flap tissue viability under hypoxic conditions in reconstructive surgery. Primary epithelial cells from mice were pretreated with TSA, and assays showed enhanced resistance to hypoxia. TSA pretreatment activated the Wnt signaling pathway, characterized by increased β-catenin and decreased GSK-3β, and upregulated stem cell-related biomarkers SOX2 and OCT4. In a mouse ischemic flap model, TSA pretreatment increased the area of surviving tissue and upregulated components involved in blood vessel regeneration. The study concluded that TSA pretreatment protected free flaps against hypoxic injury by activating Wnt signaling and enhancing stem cell-related biomarker expression.
