Response to Li et al.'s 'Therapeutic Efficacy of Platelet-Rich Plasma Combining with Microneedling and Topical Minoxidil in Refractory Severe Androgenic Alopecia'

August 2025 in “ Journal of the American Academy of Dermatology ”

Miloš Pavlović

platelet-rich plasma microneedling topical minoxidil androgenic alopecia PRP Rogaine

TLDR The reported treatment depths were likely incorrect and could risk patient safety.

The response to Li et al.'s study on the triple treatment of refractory severe androgenic alopecia highlights inaccuracies in the reported depths for platelet-rich plasma injections and microneedling. The authors of the original study claimed a depth of 1 cm for plasma injections, which is deeper than typical scalp thickness, suggesting a possible error in units. Additionally, the reported microneedling depth of 0.75 cm is significantly greater than the standard range of 0.5 to 2.5 mm, potentially risking follicle damage and scarring. Correct depth values are crucial for effective treatment and patient safety.

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