Response to Lack of Association Between Comorbidities and Central Centrifugal Cicatricial Alopecia: A Retrospective Cohort Study of 153 Patients

    August 2023 in “ Journal of the American Academy of Dermatology ”
    Bonnie W. Leung, Donald A. Glass, Katherine Omueti Ayoade
    Image of study
    TLDR The letter suggests that the study's comparison group might have affected the results and calls for larger, more detailed future research.
    The letter discusses a study by Jafari et al. on 153 patients with central centrifugal cicatricial alopecia (CCCA), where no significant differences in comorbidities were found between patients with CCCA and those with nonscarring alopecia. The authors of the letter highlight that their previous study compared comorbidities between patients with CCCA and matched controls from the general population, unlike Jafari et al.'s study. They suggest that the control group in Jafari et al.'s study likely included a large portion of patients with androgenetic alopecia (AGA), which could explain the nonsignificant differences in prevalence of diabetes, dyslipidemia, etc. The authors also note differences in diagnostic methods and the possibility of patients having both CCCA and AGA. They acknowledge the limitations of both studies, including different screening for comorbidities, small sample sizes, and being from a single geographic region. They express hope for larger, more rigorous studies in the future.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 59 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  64 upvotes 11 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

    Similar Research

    5 / 1000+ results

      research SnapshotDx Quiz: May 2022

      April 2022 in “Journal of Investigative Dermatology”
      Androgenetic alopecia causes hair thinning due to increased androgen activity, treatable with minoxidil and finasteride.
      Hair Loss in Women: Causes and Treatments

      research Hair Loss in Women: Causes and Treatments

      May 2022 in “Journal of the Egyptian Women's Dermatologic Society (Print)”
      Women's hair loss can be due to hormonal changes and various conditions, with treatments focusing on stopping progression and managing symptoms.
      Hair and Nails: Insights from 2009 Studies

      research Hair and Nails: Insights from 2009 Studies

      July 2009 in “Medical & surgical dermatology”
      Low-dose acitretin helps nail psoriasis, stem cells may treat scarring alopecia, Chinese men have lower baldness rates, lateral foldplasty is good for ingrown toenails, hair diameter helps diagnose female baldness, childhood trauma linked to alopecia areata, certain hair-weaving leads to scalp conditions in African American women, and new methods for hair research and understanding hair and sweat gland development were introduced.