Complete Clinical and Trichoscopic Remission of Refractory Patch Alopecia Areata with a Multi-Modal Microneedling and Vitamin D3 Protocol: A Case Report

November 2025 in “ Bioscientia Medicina Journal of Biomedicine and Translational Research ”

Stephanie Lukita, Ferra Olivia Mawu, Thigita A. Pandaleke

alopecia areata microneedling vitamin D3 systemic vitamin D3 supplementation topical vitamin D3

TLDR A combined treatment with microneedling and vitamin D3 led to complete hair regrowth in a woman with stubborn patch alopecia areata.

This case report describes a 44-year-old female with refractory patch alopecia areata who achieved complete clinical and trichoscopic remission using a multi-modal treatment protocol. The protocol included systemic vitamin D3 supplementation (5,000 IU/day), 10 sessions of microneedling, and topical application of high-dose vitamin D3. Significant hair regrowth was observed by week 12, with complete regrowth by week 20. The patient's vitamin D levels improved from 18.2 ng/mL to 41.5 ng/mL. While the exact contribution of each treatment component is unclear, the case suggests that a combined approach may be effective for refractory patch alopecia areata and warrants further study.

View this study on bioscmed.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community How likely is it that my hair loss is due to vitamin D deficiency and stress?

in Treatment 7 upvotes 3 years ago

A 19-year-old male suspects his hair loss is due to vitamin D deficiency and stress rather than genetics. Recommendations include taking finasteride, minoxidil, vitamin D, exercising, reducing stress, and consulting a doctor if needed.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Second update: almost 3.5 months min microneedling 1.5mm once a week ketoconazole shampoo 4 times a week

in Update 590 upvotes 3 years ago

A user's hair loss treatment regimen, which includes minoxidil, ketoconazole shampoo and microneedling; some participants questioned the results due to previous posts about hair transplants, but others agreed that quick results are possible with certain treatments.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

in Chat 55 upvotes 2 years ago

The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

community 7 months évolution of finasteride / zinc / vitamin D/ minoxidil / microneedling treatment

in Finasteride/Dutasteride 570 upvotes 3 years ago

User experienced hair loss improvement after 7 months using finasteride, zinc, vitamin D, minoxidil, and microneedling. Others praised the progress and discussed the importance of zinc and vitamin D in hair health.

Similar Research

5 / 1000+ results

Vitamin D and Its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis

research From Eye Care to Hair Growth: Bimatoprost

April 2024 in “Pharmaceuticals”

Bimatoprost helps with hair growth and eye conditions but can be costly and have side effects.