Non-responder to minoxidil for years
    Microneedling 12/27/2025

    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💧 Minoxidil (topical) 2ml 2x daily 4 years
    💊 Finasteride (oral) 1.25mg 1x daily 4 years
    💊 Vitamin D3 (oral) 8 weeks
    Microneedling 3 weeks
    the tone is 😞 negative with initial success, then no regrowth results.

    Other terms

    A 22-year-old has been using minoxidil and finasteride for hair loss with initial success, but later experienced increased shedding and no regrowth. They recently added vitamin D3 supplements and microneedling, which reduced shedding, but are seeking advice on regrowth, with suggestions to try tretinoin with minoxidil and consider dutasteride.
    View this post in the Community →

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    5 / 5 results

      community Good progress for three months?

      in Progress Pictures  83 upvotes 1 year ago
      The user reports good progress in hair growth after three months using finasteride, minoxidil with tretinoin, Alpecin C1, biotin, vitamin D3, iron, zinc, omega-3, and microneedling with rosemary/mint oil. Other users note initial shedding and discuss areas where hair growth is less effective.

      community Doing nuclear stack. Is there anything else I could do?

      in Treatment  6 upvotes 1 year ago
      The conversation discusses a comprehensive hair regrowth regimen including Dutasteride, Finasteride, microneedling, RU58841, oral and topical Minoxidil, Tretinoin, and Vitamin D3. Suggestions include dropping Finasteride, increasing Dutasteride, and considering additional treatments like caffeine, melatonin, and laser therapy, while emphasizing the effectiveness of Dutasteride and Minoxidil.

    Related Research

    6 / 6 results
      Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

      research Drug discovery for alopecia: gone today, hair tomorrow

      70 citations , February 2015 in “Expert Opinion on Drug Discovery”
      This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.
      Functional Hair Follicle Regeneration: An Updated Review

      research Functional hair follicle regeneration: an updated review

      42 citations , February 2021 in “Signal Transduction and Targeted Therapy”
      This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.
      Guidelines Based Management of Androgenetic Alopecia

      research Guidelines based management of androgenetic alopecia

      January 2014 in “Cosmoderma”
      This review examines the effectiveness of current treatments for androgenetic alopecia, offering plastic surgeons evidence-based guidance for choosing safe and effective options, but reports no new results.

      research Male androgenetic alopecia

      January 2025 in “Anais Brasileiros de Dermatologia”
      This review examines male androgenetic alopecia and reports no new clinical results, offering insights to aid dermatologists in making informed therapeutic decisions.