Regenerative Medicine to Reduce the Side Effects of Radiotherapy Causing Skin Cancer, Fibrosis, Neuropathic Pain, and Hair Loss

In this study, co-administering adipose-derived stem cells with platelet-rich plasma reduced radiation therapy-induced skin and hair follicle damage in mice, suggesting potential for clinical application.

This review discusses advancements in stem cell therapy for cutaneous radiation syndrome, highlighting the potential of various stem cell sources to improve wound healing and reduce symptoms, but reports no new clinical results.

Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.

This study reports that hair follicles can mobilize ectopic progenitors for regeneration to repair damage from ionizing radiation. Augmenting WNT signaling enhanced this regenerative process and prevented radiation- and chemotherapy-induced hair loss, highlighting a potential approach to manage alopecia during cancer treatment.

This review discusses regenerative medicine approaches for treating alopecia, including mesenchymal stem cell therapies and platelet-rich plasma, but reports no new clinical results, emphasizing the need for further study.