Clinical And Histological Recovery Of Non-Thymoma-Associated Exfoliative Dermatitis In A Cat Treated With Ciclosporin A

A 6-year-old neutered female European Shorthair cat with chronic, pruritic, alopecic, and exfoliative dermatosis unresponsive to various treatments was diagnosed with non-thymoma-associated exfoliative dermatitis. Histological examination revealed marked orthokeratotic hyperkeratosis, lymphocytic interface dermatitis, and mural folliculitis. The cat was treated with ciclosporin A (7 mg/kg daily), resulting in dramatic clinical and histological improvement within 3 weeks. The treatment was gradually reduced, and follow-up biopsies showed resolution of hyperkeratosis and inflammatory infiltrate, with recovery of sebaceous glands. This case suggested an immune-mediated process, and ciclosporin A proved effective in resolving both clinical and histological signs of the disease.