Recalcitrant Alopecia Areata Responsive to Leflunomide and Anthralin—Potentially Undiscovered JAK/STAT Inhibitors?

    October 2018 in “ Pediatric dermatology ”
    Kabir Sardana, Aastha Gupta, R. K. Gautam
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    TLDR Leflunomide and anthralin may effectively treat severe alopecia areata.
    The document discussed a case of a child with severe ophiasis-pattern alopecia areata (AA) that was unresponsive to steroid therapy. The child was successfully treated with a combination of leflunomide and anthralin, which might have worked through the inhibition of the JAK/STAT pathway. This case suggested that this combination could be a cost-effective alternative to more expensive JAK inhibitors for treating recalcitrant AA.
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