Real-World Assessment of Disease Characteristics and Clinical Outcomes in Alopecia Areata in a Global Noninterventional Observational Cohort (ADAAGIO)

This study examined real-world outcomes for 741 patients with alopecia areata (AA) and ≥50% scalp hair loss across the UK, France, Spain, and Germany. The primary focus was on the Severity of Alopecia Tool (SALT) score, with a mean initial score of 63.5. Despite a mean SALT score reduction of 44.6% at 12 months, only 10.6% of patients achieved and maintained a SALT score of ≤20 for at least 6 months. The most common treatments included topical corticosteroids, systemic and intralesional corticosteroids, systemic immunosuppressants, and minoxidil. The findings suggest that the effectiveness of these treatments may be suboptimal for achieving sustained improvement in this population.