A Randomized Controlled Trial Comparing the Efficacy of Oral Baricitinib and Methotrexate in Treating Severe Alopecia Areata

    April 2025
    Pranam Swapan Dash, Lubna Khondker, Md Alauddin Khan, Md. Shihab Talukder, Sohely Jahan, Esrat khan Lubna
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    TLDR Baricitinib is more effective than methotrexate for severe alopecia areata.
    A randomized controlled trial conducted at Bangabandhu Sheikh Mujib Medical University compared the efficacy of oral baricitinib and methotrexate in treating severe alopecia areata in 84 patients. Group A received baricitinib, while Group B received methotrexate. After 6 months, baricitinib significantly outperformed methotrexate, with a greater reduction in the Severity of Alopecia Tool (SALT) score and higher rates of excellent (SALT75) and complete (SALT90) responses. Specifically, 57.1% of patients in Group A achieved a complete response compared to none in Group B. The study concludes that baricitinib is a superior treatment option for severe alopecia areata, though further research is needed to evaluate its long-term efficacy.
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      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 3 years ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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