Rare Coexistence of Monilethrix and Trichorrhexis Nodosa in a Pediatric Patient: A Case Report

    January 2026 in “ Clinical Case Reports ”
    Yasamin Dehghan, Mozhdeh Sepaskhah
    Studysummary This case report describes a 6-year-old girl diagnosed with the rare concurrence of monilethrix and trichorrhexis nodosa, characterized by sparse, brittle hair, who showed minimal clinical improvement with low-dose oral and topical minoxidil treatment.
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    Research cited in this study 7

    1. A Nonsense Variant In KRT31 Is Associated With Autosomal-Dominant Monilethrix British journal of dermatology/British journal of dermatology, Supplement · 2024
    2. Coexisting Trichorrhexis Nodosa and Pili Annulati: A Case Report of Hair Shaft Abnormalities in a Syrian Family Annals of Medicine and Surgery · 2024
    3. Hair Shaft Disorders In Children: An Update Indian Dermatology Online Journal · 2023
    4. Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families Molecular genetics & genomic medicine · 2022
    5. Monilethrix of the Scalp from Almost Normal Aspect to Total Alopecia: Variable Intrafamilial Expressiveness Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2021
    6. Prognosis and Management of Congenital Hair Shaft Disorders with Fragility—Part I Pediatric Dermatology · 2016
    7. Novel KRT83 and KRT86 Mutations Associated with Monilethrix Experimental Dermatology · 2015