Rab5c-Mediated Endocytic Trafficking Regulates Hematopoietic Stem and Progenitor Cell Development via Notch and AKT Signaling

    April 2020 in “ PLoS Biology ”
    Jian Heng, Peng Lv, Yifan Zhang … Feng Liu
    Studysummary This study found that Rab5c is crucial for proper HSPC development in zebrafish embryos by regulating Notch and AKT signaling through endocytic trafficking, with both deficiency and overactivation leading to production defects.
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