TLDR MTX and GC combinations are the most effective for early rheumatoid arthritis.
The study compared the efficacy and safety of four treatment regimens for early rheumatoid arthritis (RA) in 118 patients over one year. The regimens included methotrexate (MTX), MTX with glucocorticoids (GC), MTX with GC and a single infusion of methylprednisolone (MP), and leflunomide (LEF). Clinical remission rates were highest in the MTX+GC (46%) and MTX+GC+MP (47%) groups, compared to MTX alone (19%) and LEF (28%). Side effects varied, with hair loss noted in several groups. Overall, the combination of MTX and GC showed the most promising results, and the total remission rate across all groups was 34%, indicating satisfactory efficacy and good tolerability.
35 citations,
October 2012 in “Dermatologic Clinics” Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.
4 citations,
June 2013 in “The Journal of Rheumatology” The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.
489 citations,
November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
70 citations,
October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.
January 2019 in “Springer eBooks” Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
