Effect of Pumpkin Seed Oil for the Treatment of Androgenetic Alopecia: Formulation and In-Vitro Evaluation

September 2022 in “ International Journal of Science and Research (IJSR) ”

Jayaram Mari Selvi, R Ananthakumar, Senthil Kumar S, R. Senthamarai

pumpkin seed oil androgenetic alopecia Carbopol 940 HPMC K100 anti-androgenic properties

TLDR The F3 pumpkin seed oil gel showed excellent properties and better drug release for hair loss treatment.

The study aimed to formulate and evaluate a pumpkin seed oil hair gel for treating androgenetic alopecia, leveraging the oil's anti-androgenic properties. The gel, composed of Carbopol 940 and HPMC K100 as gelling agents, was tested for various physical parameters, including pH, drug content, and viscosity. In-vitro release and cell cytotoxicity studies identified formulation F3 as optimized and non-irritant. The conclusion highlights that the F3 gel formulation exhibited excellent physicochemical properties and superior in vitro drug release compared to other formulations.

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