Psoriatic Alopecia: Clinical Features, Pathogenesis, And Emerging Treatment Strategies

    May 2025 in “ Skin Appendage Disorders ”
    Eitan Pirov, Yuval Ramot
    TLDR Psoriatic alopecia is a challenging hair loss condition linked to psoriasis, needing better diagnosis and personalized treatments.
    Psoriatic alopecia is an underrecognized form of hair loss associated with psoriasis, characterized by both non-scarring and scarring alopecia. The condition is driven by an inflammatory process involving the Th17/IL-23 axis, leading to hair follicle disruption and, in severe cases, permanent hair loss. Diagnosis is challenging due to overlap with other types of alopecia, and treatment responses vary. Current treatments include topical corticosteroids, vitamin D analogs, and systemic biologics, but some patients do not respond to these therapies. The condition can be paradoxically induced by TNF inhibitors, complicating management. Greater clinical recognition and research are needed to improve diagnosis and treatment, with personalized approaches and novel biologics showing promise for better patient outcomes. Further studies are necessary to optimize long-term management strategies.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 120 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 10 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community C’est terrible - at my wits end

      in Female  450 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  411 upvotes 2 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

    Similar Research

    5 / 1000+ results