Histological and Ultrastructural Evaluation of the Effect of Platelet Rich Plasma (PRP) on Wound Healing in the Tongue of Normal and Streptozotocin-Induced Diabetic Albino Rats
October 2020
in “
Egyptian Dental Journal /Egyptian Dental Journal
”
New to Platelet-Rich Plasma? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that platelet-rich plasma treatment improved wound healing in both diabetic and non-diabetic rat tongue wounds, particularly when applied before injury.
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The study evaluated the effect of Platelet Rich Plasma (PRP) on tongue wound healing in 108 normal and Streptozotocin-induced diabetic albino rats. The rats were divided into non-diabetic and diabetic groups, with subgroups receiving PRP treatment either before or after wounding. Histological and ultrastructural examinations showed that the most rapid healing occurred in subgroups treated with PRP before wounding, with significant healing observed by the 3rd day post-operation. Complete healing was noted by the 7th day in subgroups treated with PRP after wounding, similar to non-diabetic controls. Diabetic rats without PRP treatment showed delayed healing, completing by the 10th day. The study concluded that PRP application, either before or after wounding, enhanced wound healing in both diabetic and non-diabetic oral mucosal wounds.
