Histological and Ultrastructural Evaluation of the Effect of Platelet Rich Plasma (PRP) on Wound Healing in the Tongue of Normal and Streptozotocin-Induced Diabetic Albino Rats

    Mary Ramzy, Tarik Essawy, Ali Shamaa, Saher Mohammed
    TLDR PRP speeds up tongue wound healing in both diabetic and non-diabetic rats.
    The study evaluated the effect of Platelet Rich Plasma (PRP) on tongue wound healing in 108 albino rats, both normal and Streptozotocin-induced diabetic. The results indicated that PRP treatment, whether applied before or after wounding, significantly enhanced wound healing in both diabetic and non-diabetic rats. The most rapid healing was observed in subgroups treated with PRP before wounding, with significant progress by day 3 post-operation. Complete healing was achieved by day 7 in subgroups treated with PRP after wounding, similar to the non-diabetic control group. In contrast, the diabetic non-treated subgroup showed delayed healing, completing by day 10. The study concluded that PRP could effectively prevent and enhance wound healing in oral mucosal wounds for both diabetic and non-diabetic conditions.
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