Effect of Platelet-Rich Plasma in Cyclophosphamide-Induced Ovarian Failure in Albino Rats: Histological and Anatomical Study

    April 2021 in “ The Egyptian Journal of Histology ”
    Rasha El shinety, Lobna Saad Mohammed Abd Elmeged, MD Safwat, Amany Elagwany, Noha Zahran
    TLDR Platelet-rich plasma helps protect and improve ovarian function in rats treated with cyclophosphamide.
    The study investigated the effects of platelet-rich plasma (PRP) on cyclophosphamide-induced ovarian failure in albino rats. Conducted on 29 rats, with 24 female rats divided into control, cyclophosphamide, and cyclophosphamide plus PRP groups, the research aimed to evaluate PRP's protective mechanism. Results indicated that cyclophosphamide led to degeneration of ovarian follicles and impaired ovarian function. However, the group treated with PRP showed improved ovarian follicle appearance and function. The study concluded that PRP had protective effects on ovarian tissues and functions, suggesting its potential to restore ovarian tissues when used alongside cyclophosphamide.
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