Efficacy of Different Doses of Platelet-Rich Plasma for Moderate Carpal Tunnel Syndrome: Study Protocol for a Prospective, Randomized, Controlled Trial

This study protocol outlines a double-blind, randomized controlled trial to evaluate the efficacy of different doses of Platelet-Rich Plasma (PRP) injections for treating moderate carpal tunnel syndrome (CTS). The trial will involve 60 patients, divided into two groups receiving either 3ml or 5ml PRP injections, administered twice over two weeks. The primary outcome is the change in numbness measured by the Visual Analogue Scale (VAS) from baseline to six months. Secondary outcomes include ultrasound parameters, Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) scores, and nerve conduction metrics. The study aims to determine the optimal PRP dosage for CTS treatment and provide clinical guidance on injection therapy.