Special Issue: Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials

The Special Issue on regenerative therapy using blood-derived biomaterials discusses the challenges and advancements in platelet-rich plasma (PRP) therapy. While PRP has shown efficacy in preclinical studies, its clinical effectiveness is inconsistent due to a lack of robust randomized clinical trials and factors affecting older adults. The issue includes nine papers on PRP's application in osteoarthritis, ocular diseases, and sports medicine. Findings indicate that PRP's success depends on the quality of the PRP and the patient's condition, with athletes potentially benefiting more due to their enhanced anti-inflammatory response. The issue also explores alternative therapies like autologous conditioned serum and platelet lysates, highlighting the need for better patient selection criteria and standardized protocols to improve PRP therapy outcomes.