The Effects of Probiotics, Prebiotics, and Synbiotics Supplementation on Polycystic Ovary Syndrome: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

    September 2022 in “ Research Square (Research Square)
    Sepide Talebi, Sheida Zeraattalab-Motlagh, Nastaran Payandeh, Yahya Jalilpiran‬, Shakila Ansari, Hamed Mohammadi, Kurosh Djafarian, Mahsa Ranjbar, Sara Sadeghi, Mahdiyeh Taghizadeh, Sakineh Shab‐Bidar
    TLDR Probiotics and synbiotics may help with PCOS symptoms, but more research is needed.
    This umbrella review of meta-analyses of randomized controlled trials assessed the effects of pro-, pre-, and synbiotics supplementation on women with polycystic ovary syndrome (PCOS). The study found that probiotic supplementation significantly reduced insulin resistance and fasting glucose concentration, while synbiotic supplementation improved glycemic control, lipid profile, and hormonal parameters, though the evidence was of low to very low certainty. Prebiotics supplementation also showed reductions in waist/hip circumference, fasting glucose, lipid profile, and other PCOS-related outcomes, but with low certainty. Overall, while some beneficial effects were observed, the evidence was not strong, indicating a need for further well-designed trials to confirm these findings.
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