Forensic DNA phenotyping (FDP) from low template DNA (LT-DNA) has advanced with the integration of machine learning (ML) models, improving predictive accuracy for traits like eye and hair color, with AUC > 0.9 for eye color and up to 15% improvement in SNP recovery. Tools such as HIrisPlex-S and VISAGE panels are effective for eye and hair color prediction, though challenges remain for skin tone, age, and facial morphology, especially in admixed populations. Future efforts should focus on multi-omics integration, portable sequencing, and inclusive datasets to enhance accuracy and ethical compliance in forensic applications.
4 citations
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March 2024 in “Forensic Sciences Research” Forensic DNA phenotyping faces challenges like inconsistent terms and limited genetic knowledge.
89 citations
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