Polyglandular Syndrome Type 1 Complicated with Dilated Cardiomyopathy: A Case Report

    April 2024 in “ Research Square (Research Square) ”
    S. Abidi, Faizan Rasheed, Ravinder Reddy, Reshmi Francis Vadakkan, Afrasayab Khan, Navya Pillikunte Doddereddy, A Quadri, Salma Younas
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    TLDR A 27-year-old with APS-1 showed improvement in symptoms after treatment.
    This case report discusses a 27-year-old male with autoimmune polyglandular syndrome type 1 (APS-1), presenting with fever, dysarthria, dysphagia, oral candidiasis, nail dystrophy, and alopecia since age 7. He was later diagnosed with hypoparathyroidism and dilated cardiomyopathy. Laboratory results showed hypocalcemia, hyperphosphatemia, and low PTH levels, confirming APS-1. A brain CT scan revealed bilateral symmetrical calcifications. Treatment included oral calcium, antifungal suspension, and medications for cardiomyopathy. The patient's dysphagia and dysarthria improved after treating candidiasis. This case highlights the varied manifestations of APS-1.
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