Number of PMN Cells, MN, Fibroblasts, Angiogenesis in Alloxan-Induced Diabetic Mice

December 2024 in “ JURNAL ANALIS LABORATORIUM MEDIK ”

Shiva Nur Rahmawaty, Suyarta Efrida Pakpahan

fibroblasts angiogenesis PMN cells MN cells wound healing diabetic mice alloxan

TLDR Diabetic wounds heal slower than healthy wounds.

This study investigates wound healing in diabetic mice induced with alloxan, focusing on cell counts of PMN, MN, fibroblasts, and angiogenesis at days 3, 7, 14, and 21. Using 24 male mice divided into diabetic and healthy groups, the research found that healthy mice exhibited faster wound closure macroscopically compared to diabetic mice (p<0.001). Microscopically, diabetic mice showed increased PMN and MN cells from the inflammatory to remodeling phases (p<0.001). Overall, the study concludes that diabetic wounds heal slower both macroscopically and microscopically compared to healthy wounds.

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Number of PMN Cells, MN, Fibroblasts, Angiogenesis in Alloxan-Induced Diabetic Mice

Research cited in this study

research M-CSF-Stimulated Myeloid Cells Can Convert Into Epithelial Cells to Participate in Re-Epithelialization and Hair Follicle Regeneration During Dermal Wound Healing

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