Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

The study demonstrated that platelet-rich plasma (PRP) significantly accelerated skin wound healing in C57/BL6 mice by modulating local inflammation, enhancing angiogenesis, and promoting re-epithelialization. PRP treatment reduced inflammatory cytokines and increased growth factors like vascular endothelial growth factor and insulin-like growth factor-1, which contributed to improved wound healing. Additionally, PRP enhanced the survival, migration, and proliferation of epidermal stem cells (ESCs), facilitating their differentiation into adult cells. These findings suggested that PRP could be a promising treatment for wound healing, although further investigation into the regulatory mechanisms was needed.