Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

The review examines the integration of platelet concentrates (PCs) and mesenchymal stem cells (MSCs) to enhance regenerative therapies. It highlights the potential benefits of preconditioning MSCs with PCs, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), to improve therapeutic efficacy. Key signaling pathways like ERK/MAPK and PI3K/Akt are activated, enhancing MSCs' regenerative capabilities and resistance to stress. The combination of these strategies shows promise in wound healing, cartilage repair, and immunomodulation, with synergistic effects leading to improved tissue regeneration and repair outcomes. However, the effectiveness of these combined treatments can vary, and further research is needed to optimize clinical applications.